Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT 2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Compare Nefazodone vs. Trazodone, which is better for uses like: Depression, Anxiety and Major Depression. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Nefazodone 3.8/5 over Trazodone 3.3/5 in overall satisfaction. Nefazodone and Trazodone study guide by abecasim includes 102 questions covering vocabulary, terms and more. Quizlet flashcards, activities and games help you improve your grades. Quizlet flashcards, activities and games help you improve your grades. Depression. Serotonin antagonists are another class of antidepressants. The examples are Trazodone and Nefazodone. THe mechanism of action of these drugs are described. The side effects are described along with potential interaction with other drugs. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately. Nefazodone may increase TST but has no consistent effect on sleep latency, SWS, or REM sleep. 9, 42 One study in normal individuals demonstrated an increase in MSLT mean latency (i.e., decreased sleepiness) after 16 days of nefazodone treatment. 43 Trazodone impairs performance in healthy individuals, 44 but data on depressed individuals are inconclusive. Nefazodone may slow down how quickly your body processes your buspirone. If you are taking a higher dose of buspirone, buspirone may slow down how quickly your liver processes nefazodone. This table shows only those adverse events for which there was a statistically significant difference (p ≤ 0.05) in incidence between the Nefazodone dose ranges as well as a difference between the high dose range and placebo. Common Questions and Answers about Nefazodone and sleep serzone ) - Ambiem , Xanax, Trazodone, Temazepam, Serax, Lorazepam - SERZONE acted as a DUAL agent, it helped life the Major Depression and reset my Sleep to the broken sleep it is, and squashed HORRIBILE Anxiety. Compared with trazodone, nefazodone has a lesser risk of priapism (prolonged penile erection). Although the erection usually subsides eventually, occasionally blood clots form within the penis and cause serious damage to the penis.